On February 28, 2025, the royal family of Luxembourg suffered a painful loss with the passing of Prince Federico, who was only 22 years old. The young man, son of Roberto of Luxembourg and Julie of Nassau, had been battling a rare disease since his adolescence. The news was just revealed now.
On the day that marked Rare Disease Day, Federico called his family to say goodbye in an emotional manner. According to his father, the farewell was filled with wisdom and tenderness, in Federico's unique style. In that last meeting, he even shared one last family joke, showing the humor Federico had.
One of the most moving moments was when Federico asked his father: "Dad, are you proud of me?" The clarity of these words, after several days without being able to speak, surprised everyone, leaving a deep mark. In response, Roberto assured him that he was, reaffirming his son's legacy, who, according to his father, left a profound impression on everyone who knew him.
Federico, su padre Roberto, su madre Julie y sus hermanos, Charlotte y Alexander.
Federico was diagnosed at 14 with POLG, a mitochondrial genetic disorder that affects the energy of the body's cells, causing progressive dysfunction of various organs. This diagnosis transformed his life, but it didn't stop him from being a source of inspiration to raise awareness about the disease.
A legacy of hope
Despite the challenges he faced, Federico left a legacy full of positivity, joy, and determination. His father described him as a young man with exceptional social skills, an admirable sense of humor, and infinite compassion. Federico's strength was reflected not only in his character but also in his ability to inspire through the POLG Foundation, of which he was the director.
El príncipe Federico de Luxemburgo.
"On Friday, his Duolingo and Italian exercise alarm went off like any other day... but this wasn't a normal day. This would be his last in this world…and Rare Disease Day, a day created to raise awareness and bring about change for people living with one of these orphan diseases and, of course, for their families and precious caregivers," said his father in the statement from the POLG Foundation.
